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To overcome these limitations, several new strategies are being explored for cytoplasmic delivery and lysosomal escape 137,138

One of the concepts emerging from these observations is the role of non-rhythmic tonic signals as circadian tuners (or tongeber German for sound giver in reference to the term zeitgeber (time giver) describing a phasic modulator of circadian rhythms)

Physiology 26, 148152

By contrast, ATF6 activation positively correlates with the severity of atherosclerotic lesion and accelerates plaque development by facilitating cholesterol accumulation (157)